FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.

@article{Chambraud1996FAP48AN,
  title={FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.},
  author={B{\'e}atrice Chambraud and Christine Radanyi and Jacques H Camonis and Kamran Shazand and Krzysztof M. Rajkowski and Etienne Emile Baulieu},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 51},
  pages={
          32923-9
        }
}
We have identified a human gene encoding a 48-kDa protein that specifically interacts with the peptidyl prolyl isomerase FK506-binding protein 59 (FKBP59) and also with the well known FKBP12. FKBP59 and FKBP12 belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. The yeast two-hybrid system was used to isolate target proteins that interact with the immunosuppressant drug binding domain of the rabbit FKBP59. The cDNA for an as yet… CONTINUE READING

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