FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

  title={FANCI is a second monoubiquitinated member of the Fanconi anemia pathway},
  author={Ashley E Sims and Elizabeth J. Spiteri and Robert Joseph Sims and Adriana G Arita and Francis Peter Lach and Thomas F. Landers and Melanie Wurm and Marcel Freund and Kornelia Neveling and Helmut Hanenberg and Arleen D. Auerbach and Tony T Huang},
  journal={Nature Structural &Molecular Biology},
Activation of the Fanconi anemia (FA) DNA damage–response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence–based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line. 
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Cell, published online 3 April

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