FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.

  title={FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.},
  author={Simonne Longerich and Joseph San Filippo and Dongqing Liu and Patrick Sung},
  journal={The Journal of biological chemistry},
  volume={284 35},
FANCI is integral to the Fanconi anemia (FA) pathway of DNA damage repair. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 and relocalizes to chromatin, where it functions with monoubiquitinated FANCD2 to facilitate DNA repair. We show that FANCI and its C-terminal fragment possess a DNA binding activity that prefers branched structures. We also demonstrate that FANCI can be ubiquitinated on Lys-523 by the UBE2T-FANCL pair in vitro. These findings should facilitate… CONTINUE READING


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