FAM83B mediates EGFR- and RAS-driven oncogenic transformation.

  title={FAM83B mediates EGFR- and RAS-driven oncogenic transformation.},
  author={Rocky Cipriano and J. Graham and Kristy L. S. Miskimen and Benjamin L. Bryson and Ronald C. Bruntz and Sarah A. Scott and Haley A Brown and George R Stark and Mark W Jackson},
  journal={The Journal of clinical investigation},
  volume={122 9},
Aberrant regulation of growth signaling is a hallmark of cancer development that often occurs through the constitutive activation of growth factor receptors or their downstream effectors. Using validation-based insertional mutagenesis (VBIM), we identified family with sequence similarity 83, member B (FAM83B), based on its ability to substitute for RAS in the transformation of immortalized human mammary epithelial cells (HMECs). We found that FAM83B coprecipitated with a downstream effector of… CONTINUE READING
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