FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga.

@article{Chiramel2016FAM134BTS,
  title={FAM134B, the Selective Autophagy Receptor for Endoplasmic Reticulum Turnover, Inhibits Replication of Ebola Virus Strains Makona and Mayinga.},
  author={Abhilash I. Chiramel and J. D. Dougherty and V. S. S. Nair and Shelly J. Robertson and Sonja M. Best},
  journal={The Journal of infectious diseases},
  year={2016},
  volume={214 suppl 3},
  pages={
          S319-S325
        }
}
Selective autophagy of the endoplasmic reticulum (termed ER-phagy) is controlled by members of the FAM134 reticulon protein family. Here we used mouse embryonic fibroblasts from mice deficient in FAM134B to examine the role of the ER in replication of historic (Mayinga) or contemporary (Makona GCO7) strains of Ebola virus (EBOV). Loss of FAM134B resulted in 1-2 log10 higher production of infectious EBOV, which was associated with increased production of viral proteins GP and VP40 and greater… CONTINUE READING
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