FAK regulates biological processes important for the pathogenesis of cancer

@article{GabarraNiecko2004FAKRB,
  title={FAK regulates biological processes important for the pathogenesis of cancer},
  author={Veronica Gabarra-Niecko and Michael D. Schaller and Jill M. Dunty},
  journal={Cancer and Metastasis Reviews},
  year={2004},
  volume={22},
  pages={359-374}
}
Since its initial discovery as a substrate and binding partner for the Src oncogene, a role for the focal adhesion kinase (FAK) in cancer has been speculated. In this review the clinical evidence correlating FAK overexpression with cancer and the experimental evidence demonstrating that FAK can control some phenotypes associated with cancer will be discussed. In addition, the emerging theme of interactions between the FAK and growth factor signaling pathways will be described. The evidence… 

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