FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.

@article{Liu2007FAKIR,
  title={FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.},
  author={Shangxi Liu and Shi-wen Xu and Laura A Kennedy and Daphne Pala and Yunliang Chen and Mark Eastwood and David E. Carter and Carol Mary Black and David J. Abraham and Andrew Leask},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 6},
  pages={
          2169-78
        }
}
Transforming growth factor beta (TGFbeta) plays a critical role in connective tissue remodeling by fibroblasts during development, tissue repair, and fibrosis. We investigated the molecular pathways in the transmission of TGFbeta signals that lead to features of connective tissue remodeling, namely formation of an alpha-smooth muscle actin (alpha-SMA) cytoskeleton, matrix contraction, and expression of profibrotic genes. TGFbeta causes the activation of focal adhesion kinase (FAK), leading to… CONTINUE READING

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