FAK and talin during assembly of integrin adhesions on fibronectin. They show that FAK is upstream of talin, and that talin is not required for FAK recruitment or for integrin activation at nascent adhesions

Abstract

Integrins are transmembrane extracellular matrix receptors that not only mediate physical attachment between a cell and its environment, but also permit transduction of signals to control shape, motility, and the cell cycle in response to environmental cues. Integrin adhesions exist in multiple forms in cells, for example focal complexes, focal adhesions… (More)

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