FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

@inproceedings{TaliaferroSmith2015FAKAI,
  title={FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells},
  author={LaTonia D. Taliaferro-Smith and Elaine Oberlick and Tongrui Liu and Tanisha Z. McGlothen and Tiffanie Alcaide and Rachel E Tobin and Siobhan M. Donnelly and Rachel Commander and Erik R. Kline and Ganji Purnachandra Nagaraju and Lauren S. Havel and Adam I. Marcus and Rita Nahta and Ruth M O'regan},
  booktitle={Oncotarget},
  year={2015}
}
Triple negative breast cancer (TNBC) is a highly metastatic disease that currently lacks effective prevention and treatment strategies. The insulin-like growth factor 1 receptor (IGF1R) and focal adhesion kinase (FAK) signaling pathways function in numerous developmental processes, and alterations in both are linked with a number of common pathological diseases. Overexpression of IGF1R and FAK are closely associated with metastatic breast tumors. The present study investigated the… CONTINUE READING
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Comparative Expression Profiles of E-cadherin and Vimentin in Triple Negative and Estrogen Receptor-Positive Breast Carcinoma

  • MJ CCSwadley, HC Sullivan, DJ Williams, L TaliaferroSmith, GM Oprea, AL. Adams
  • United States and Canadian Academy of Pathology…
  • 2012
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