FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing

@inproceedings{Owen2011FAKRI,
  title={FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing},
  author={Katherine A. Owen and Michelle Y. Abshire and Robert W. Tilghman and James E. Casanova and Amy H. Bouton},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Following damage to the intestinal epithelium, restoration of epithelial barrier integrity is triggered by a robust proliferative response. In other tissues, focal adhesion kinase (FAK) regulates many of the cellular processes that are critical for epithelial homeostasis and restitution, including cell migration, proliferation and survival. However, few studies to date have determined how FAK contributes to mucosal wound healing in vivo. METHODOLOGY AND PRINCIPAL FINDINGS To… CONTINUE READING
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