FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β

@inproceedings{Gao2015FAKPYK2PT,
  title={FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β},
  author={Chenxi Gao and Guangming Chen and S. Kuan and Dennis Han Zhang and David D. Schlaepfer and Jing Hu and Jonathan A Cooper},
  booktitle={eLife},
  year={2015}
}
Aberrant activation of Wnt/β-catenin signaling plays an unequivocal role in colorectal cancer, but identification of effective Wnt inhibitors for use in cancer remains a tremendous challenge. New insights into the regulation of this pathway could reveal new therapeutic point of intervention, therefore are greatly needed. Here we report a novel FAK/PYK2/GSK3… CONTINUE READING