FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern.

@article{Menegon1999FAKAP,
  title={FAK+ and PYK2/CAKbeta, two related tyrosine kinases highly expressed in the central nervous system: similarities and differences in the expression pattern.},
  author={Andrea Menegon and Ferr{\'a}n Burgaya and Pierre Baudot and David D. Dunlap and Jean Antoine Girault and Flavia Valtorta},
  journal={The European journal of neuroscience},
  year={1999},
  volume={11 11},
  pages={3777-88}
}
Focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2/cell adhesion kinase beta (PYK2/CAKbeta) are related, non-receptor, cytoplasmic tyrosine kinases, highly expressed in the central nervous system (CNS). In addition, FAK+ is a splice isoform of FAK containing a 3-amino acid insertion in the carboxy-terminal region. In rat hippocampal slices, FAK+ and PYK2/CAKbeta are differentially regulated by neurotransmitters and depolarization. We have studied the regional and cellular… CONTINUE READING
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