FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration

@inproceedings{MartnezMrmol2016FAIMLRO,
  title={FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration},
  author={Ramon Mart{\'i}nez-M{\'a}rmol and Bruna Barneda-Zahonero and David Soto and Rosa Mar{\'i}a Andr{\'e}s and Elena Coccia and Xavier Gasull and Laura Planells-Ferrer and Rana S. Moubarak and Eduardo Soriano and Joan X Comella},
  booktitle={Scientific reports},
  year={2016}
}
Caspases have recently emerged as key regulators of axonal pruning and degeneration and of long-term depression (LTD), a long-lasting form of synaptic plasticity. However, the mechanism underlying these functions remains unclear. In this context, XIAP has been shown to modulate these processes. The neuron-specific form of FAIM protein (FAIM-L) is a death receptor antagonist that stabilizes XIAP protein levels, thus preventing death receptor-induced neuronal apoptosis. Here we show that FAIM-L… CONTINUE READING
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