FAILURE OF FIBRONECTIN AS AN OPSONIN IN THE HOST DEFENCE SYSTEM: A CASE OF COMPETITIVE SELF INHIBITION?

@article{Brown1983FAILUREOF,
  title={FAILURE OF FIBRONECTIN AS AN OPSONIN IN THE HOST DEFENCE SYSTEM: A CASE OF COMPETITIVE SELF INHIBITION?},
  author={RobertA. Brown},
  journal={The Lancet},
  year={1983},
  volume={322},
  pages={1058-1060}
}
In the course of various clinical conditions, consumption of opsonic fibronectin is thought to impair the function of the reticuloendothelial (RE) host defence system. Despite evidence to support its central role in host defence, measurements of circulating fibronectin levels appear to have limited diagnostic or prognostic value. It seems that the problem may be more complex than a simple depletion of fibronectin. It is proposed that the structure of fibronectin can allow a condition of opsonic… CONTINUE READING
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