FADDdel-GFP modified mouse insulinoma cells counteract the cytotoxicity of reactive T cells.

Abstract

IDDM results from pancreatic beta cell destruction by islet-reactive T cells, a process that involves beta cell apoptosis. Fas-FasL pathway plays a major role in pancreatic beta cell death. Fas-associated death domain protein (FADD), the component of the tumor necrosis factor receptor type 1 (TNFR1) and Fas signaling complexes, is involved in TNFR1- and Fas… (More)

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Cite this paper

@article{Hu2004FADDdelGFPMM, title={FADDdel-GFP modified mouse insulinoma cells counteract the cytotoxicity of reactive T cells.}, author={Ping Hu and Guohua Wang and Xiaohua Zhu and Jing Yang and Huifen Zhu and Zihui Xu and Wenjun Liao and Xiao Liu and Fen Xu and Jiao Yin and Guan Xin Shen}, journal={Cellular & molecular immunology}, year={2004}, volume={1 5}, pages={383-6} }