FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.

@article{Wang2005FADDdependentAI,
  title={FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene.},
  author={Yongbao Wang and Bo Wang and Jinchun Cheng and Li Yang and Zhong-Li Liu and Kannan V Balan and Panayotis Pantazis and James H. Wyche and Zhiyong Han},
  journal={Biochemical pharmacology},
  year={2005},
  volume={69 2},
  pages={249-54}
}
The plant-produced compound, resveratrol (3,5,4'-trihydroxy-trans-stilbene, 3,4,5-THS), induces apoptosis in various human leukemia cell types in vitro, and thus appears to be a promising anti-leukemia agent. In this study, we observed that treatment of resveratrol-resistant Jurkat cells with the resveratrol analogue, 3,4,5-trihydroxy-trans-stilbene (3,4,5-THS), rapidly induced extensive apoptosis, indicating that the apoptotic activity of the analogue differed from that of the parental… CONTINUE READING

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