FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.

Abstract

Fas-associated death domain protein (FADD) and caspase-8 (casp8) are vital intermediaries in apoptotic signaling induced by tumor necrosis factor family ligands. Paradoxically, lymphocytes lacking FADD or casp8 fail to undergo normal clonal expansion following antigen receptor cross-linking and succumb to caspase-independent cell death upon activation. Here… (More)
DOI: 10.1073/pnas.0808597105

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