FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

  title={FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis},
  author={Arul M. Chinnaiyan and Karen O'Rourke and Muneesh Tewari and Vishva M. Dixit},
Using the cytoplasmic domain of Fas in the yeast two-hybrid system, we have identified a novel interacting protein, FADD, which binds Fas and Fas-FD5, a mutant of Fas possessing enhanced killing activity, but not the functionally inactive mutants Fas-LPR and Fas-FD8. FADD contains a death domain homologous to the death domains of Fas and TNFR-1. A point mutation in FADD, analogous to the lpr mutation of Fas, abolishes its ability to bind Fas, suggesting a death domain to death domain… CONTINUE READING
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