FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains

@article{Lobo2006FACSarrayPO,
  title={FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains},
  author={Mary Kay Lobo and Stanislav L. Karsten and M. Gray and Daniel H. Geschwind and X William Yang},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={443-452}
}
A major challenge in systems neuroscience is to perform precise molecular genetic analyses of a single neuronal population in the context of the complex mammalian brain. Existing technologies for profiling cell type–specific gene expression are largely limited to immature or morphologically identifiable neurons. In this study, we developed a simple method using fluorescent activated cell sorting (FACS) to purify genetically labeled neurons from juvenile and adult mouse brains for gene… CONTINUE READING