FAAH genetic variation enhances fronto-amygdala function in mouse and human

@inproceedings{Dincheva2015FAAHGV,
  title={FAAH genetic variation enhances fronto-amygdala function in mouse and human},
  author={Iva Dincheva and Andrew T. Drysdale and Catherine A Hartley and David Cassells Johnson and Deqiang Q Jing and Elizabeth C. King and Stephen Ra and Marcus A. Gray and Ruirong Yang and Ann Marie DeGruccio and Chienchun Huang and Benjamin F Cravatt and Charles E. Glatt and Matthew Nicholas Hill and B. J. Casey and Francis Sang Yong Lee},
  booktitle={Nature communications},
  year={2015}
}
Cross-species studies enable rapid translational discovery and produce the broadest impact when both mechanism and phenotype are consistent across organisms. We developed a knock-in mouse that biologically recapitulates a common human mutation in the gene for fatty acid amide hydrolase (FAAH) (C385A; rs324420), the primary catabolic enzyme for the endocannabinoid anandamide. This common polymorphism impacts the expression and activity of FAAH, thereby increasing anandamide levels. Here, we show… CONTINUE READING
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