FAAH and anandamide: is 2-AG really the odd one out?

  title={FAAH and anandamide: is 2-AG really the odd one out?},
  author={Vincenzo Di Marzo and Mauro Maccarrone},
  journal={Trends in pharmacological sciences},
  volume={29 5},
Fatty acid amide hydrolase (FAAH) is a hydrolytic enzyme that recognizes as substrates and inactivates the two most studied endocannabinoids, anandamide and 2-arachidonoylglycerol (2-AG). Following the observation that endocannabinoids produced by tissues during pathological conditions often have protective roles, FAAH inhibitors have been proposed as therapeutic drugs. Yet it has been suggested that FAAH functions in vivo only as an anandamide-degrading enzyme because its pharmacological and… CONTINUE READING