F15063, a potential antipsychotic with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. I. In vitro receptor affinity and efficacy profile.

@article{NewmanTancredi2007F15063AP,
  title={F15063, a potential antipsychotic with D2/D3 antagonist, 5-HT 1A agonist and D4 partial agonist properties. I. In vitro receptor affinity and efficacy profile.},
  author={Adrian Newman-Tancredi and M. B. Assi{\'e} and J. Martel and Cristina Cosi and Liesbeth A. Bruins Slot and Christiane Palmier and Isabelle Rauly-Lestienne and F. C. Colpaert and Bernard Y Vacher and Didier Cussac},
  journal={British journal of pharmacology},
  year={2007},
  volume={151 2},
  pages={237-52}
}
BACKGROUND AND PURPOSE Combining 5-HT(1A) receptor activation with dopamine D(2)/D(3) receptor blockade should improve negative symptoms and cognitive deficits in schizophrenia. We describe the in vitro profile of F15063 (N-[(2,2-dimethyl-2,3-dihydro-benzofuran-7-yloxy)ethyl]-3-(cyclopent-1-enyl)-benzylamine). EXPERIMENTAL APPROACH F15063 was characterised in tests of binding affinity and in cellular models of signal transduction at monoamine receptors. KEY RESULTS Affinities (receptor and… CONTINUE READING
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