F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation.

@article{Palmer2010FspondinRC,
  title={F-spondin regulates chondrocyte terminal differentiation and endochondral bone formation.},
  author={Glyn D. Palmer and Alejandro H Piton and Lwin Mon Thant and Serafim M. Oliveira and Marina D'Angelo and Mukundan G. Attur and Steven B. Abramson and Cristina C Teixeira},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2010},
  volume={28 10},
  pages={1323-9}
}
This study examines the role of F-spondin, an extracellular matrix protein of osteoarthritic cartilage, during chondrocyte maturation in embryonic growth plate cartilage. In chick tibia, F-spondin expression localized to the hypertrophic and calcified zones of the growth plate. Functional studies using tibial organ cultures indicated that F-spondin inhibited (∼35%, p = 0.02), and antibodies to F-spondin increased (∼30%, p < 0.1) longitudinal limb growth relative to untreated controls. In cell… CONTINUE READING