F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function.

@article{Pazhouhandeh2006FboxlikeDI,
  title={F-box-like domain in the polerovirus protein P0 is required for silencing suppressor function.},
  author={Maghsoud Pazhouhandeh and Monika Dieterle and Katia Marrocco and Esther Lechner and Bassam Berry and Veronique Brault and Odile Hemmer and Thomas Kretsch and Kenneth E Richards and Pascal Genschik and V{\'e}ronique Ziegler-Graff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 6},
  pages={1994-9}
}
Plants employ small RNA-mediated posttranscriptional gene silencing as a virus defense mechanism. In response, plant viruses encode proteins that can suppress RNA silencing, but the mode of action of most such proteins is poorly understood. Here, we show that the silencing suppressor protein P0 of two Arabidopsis-infecting poleroviruses interacts by means of a conserved minimal F-box motif with Arabidopsis thaliana orthologs of S-phase kinase-related protein 1 (SKP1), a component of the SCF… CONTINUE READING
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