F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs.

@article{Jones1999FactinSI,
  title={F-actin stabilization increases tension cost during contraction of permeabilized airway smooth muscle in dogs.},
  author={Keith A. Jones and William A. Perkins and Robert R Lorenz and Y. K. Subrahmanya Prakash and G C Sieck and David O. Warner},
  journal={The Journal of physiology},
  year={1999},
  volume={519 Pt 2},
  pages={527-38}
}
1. Dynamic actin reorganization involving actin polymerization and depolymerization may play an important functional role in smooth muscle. 2. This study tested the hypothesis that F-actin stabilization by phalloidin increases tension cost (i.e. ATP hydrolysis rate per unit of isometric force) during Ca2+-induced activation of Triton X-100-permeabilized canine tracheal smooth muscle. 3. Adenosine 5'-triphosphate (ATP) hydrolysis rate was quantified using an enzyme-coupled NADH fluorometric… CONTINUE READING

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