F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

@inproceedings{Babich2012FactinPA,
  title={F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation},
  author={Alexander D. Babich and Shuixing Li and Roddy S. O'Connor and Michael C Milone and Bruce D Freedman and Janis K Burkhardt},
  booktitle={The Journal of cell biology},
  year={2012}
}
Activation of T cells by antigen-presenting cells involves assembly of signaling molecules into dynamic microclusters (MCs) within a specialized membrane domain termed the immunological synapse (IS). Actin and myosin IIA localize to the IS, and depletion of F-actin abrogates MC movement and T cell activation. However, the mechanisms that coordinate actomyosin dynamics and T cell receptor signaling are poorly understood. Using pharmacological inhibitors that perturb individual aspects of… CONTINUE READING

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