F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin.

@article{Wakimoto2013FactinMM,
  title={F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin.},
  author={Hiroshi Wakimoto and Masakatsu Shimodo and Yuto Satoh and Yoshinori Kitagawa and Kaoru Takeuchi and Bin Gotoh and Masae Itoh},
  journal={Journal of virology},
  year={2013},
  volume={87 4},
  pages={
          1974-84
        }
}
Actin filament (F-actin) is believed to be involved in measles virus (MV) assembly as a cellular factor, but the precise roles remain unknown. Here we show that Phe at position 50 of the MV matrix (M) protein is important for its association with F-actin, through which the function of the M protein is regulated. In plasmid-expressed or MV-infected cells, a coimmunoprecipitation study revealed that the wild-type M (M-WT) protein associated strongly with F-actin but only weakly with the… CONTINUE READING
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