F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2

  title={F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2},
  author={Danielle Burger and C{\'e}line Fickentscher and Philippe de Moerloose and Karim J Brandt},
  booktitle={Scientific reports},
NLRP3 and ASC are able to form a large multimeric complex called inflammasome in response to a number danger signals. The NLRP3 inflammasome is required for the activation of caspase-1 and subsequent maturation of pro-IL-1β into active IL-1β. Although the mechanisms regulating the formation and activity of NLRP3 inflammasome are yet not fully elucidated, data suggest that the assembly of NLRP3 inflammasome requires microtubules to induce the proximity of ASC and NLRP3. In this study we show… CONTINUE READING

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Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.

Proceedings of the National Academy of Sciences of the United States of America • 2014

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