F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors.

@article{Rist1997FactinCA,
  title={F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors.},
  author={R J Rist and Ignacio Andres Romero and Michael W-Y Chan and Pierre Olivier Couraud and Françoise Roux and N Joan Abbott},
  journal={Brain research},
  year={1997},
  volume={768 1-2},
  pages={10-8}
}
The immortalised RBE4 cell line, derived from rat brain capillary endothelial cells, preserves many features of the in vivo brain endothelium, and hence is of interest as a potential in vitro model of the blood-brain barrier (BBB). This study reports the effects of elevated intracellular cAMP and factors released by astrocytes on the F-actin cytoskeleton and paracellular sucrose permeability of monolayers of RBE4 cells. RBE4 cells grown in control medium showed a marked increase in the F-actin… CONTINUE READING
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