F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.

@article{Murrell2012FactinBC,
  title={F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.},
  author={Michael P. Murrell and Margaret L. Gardel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 51},
  pages={20820-5}
}
Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted by myosin thick filaments. Myosin motors generate both compressive and tensile stresses on F-actin and consequently induce large bending fluctuations, which reduces their effective persistence length to <1 μm. Over a large range of conditions, we show the extent of network contraction corresponds exactly to the… CONTINUE READING

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