Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment

@article{Heiska2011EzrinIK,
  title={Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment},
  author={Leena Heiska and Maria M Melikova and Feng Zhao and Ichiko Saotome and Andrea I McClatchey and Olli Carp{\'e}n},
  journal={Oncogene},
  year={2011},
  volume={30},
  pages={4953-4962}
}
The oncogenic tyrosine kinase Src has a role in cancer development, especially by promoting invasive and metastatic behavior. It is, however, unclear which of the Src-regulated signaling cascades induce malignant phenotype in three-dimensional environment. One of Src substrates is ezrin, a cytoskeletal organiser and regulator of signal transduction. Ezrin expression correlates with poor outcome of diverse cancers and is essential in experimental metastatic osteosarcoma. We reconstituted… CONTINUE READING