Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway.

@article{Gautreau1999EzrinAP,
  title={Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway.},
  author={Alexis Gautreau and Patrick Poullet and Daniel Louvard and Monique Arpin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 13},
  pages={7300-5}
}
ERM (Ezrin-Radixin-Moesin) proteins function as plasma membrane-actin cytoskeleton linkers and participate in the formation of specialized domains of the plasma membrane. We have investigated ezrin function in tubulogenesis of a kidney-derived epithelial cell line, LLC-PK1. Here we show that cells overproducing a mutant form of ezrin in which Tyr-353 was changed to a phenylalanine (Y353F) undergo apoptosis when assayed for tubulogenesis. While investigating the mechanism responsible for this… CONTINUE READING
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