Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis.

@article{Hatano2013EzrinAM,
  title={Ezrin, a membrane cytoskeletal cross-linker, is essential for the regulation of phosphate and calcium homeostasis.},
  author={Ryo Hatano and Eiko Fujii and Hiroko Segawa and Kenichi Mukaisho and Mitsunobu Matsubara and Ken-Ichi Miyamoto and Takanori Hattori and Hiroyuki Sugihara and Shinji Asano},
  journal={Kidney international},
  year={2013},
  volume={83 1},
  pages={41-9}
}
Ezrin cross-links plasma membrane proteins with the actin cytoskeleton. In the kidney, ezrin mainly localizes at the brush border membrane of proximal tubules with the scaffolding protein, Na(+)/H(+) exchanger regulatory factor (NHERF) 1. NHERF1 interacts with the sodium/phosphate cotransporter, Npt2a. Defects in NHERF1 or Npt2a in mice cause hypophosphatemia. Here we studied the physiological role of ezrin in renal phosphate reabsorption using ezrin knockdown mice (Vil2). These mice exhibit… CONTINUE READING

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