Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.

@article{Splinter2012EzogabineA,
  title={Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.},
  author={Michele Y. Splinter},
  journal={Clinical therapeutics},
  year={2012},
  volume={34 9},
  pages={1845-56.e1}
}
BACKGROUND Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of action. It activates low-threshold voltage-gated potassium channels, leading to hyperpolarization of the membrane potential, stabilization of the resting membrane potential, and suppression of repetitive firing. OBJECTIVE This review identified the efficacy and tolerability of ezogabine in the treatment of partial-onset seizures reported in randomized controlled trials… CONTINUE READING

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