Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.

@article{Wyngaarden2011Ezh2RA,
  title={Ezh2 regulates anteroposterior axis specification and proximodistal axis elongation in the developing limb.},
  author={Laurie A Wyngaarden and Paul Delgado-Olgu{\'i}n and I-hsin Su and Benoit G Bruneau and Sevan Hopyan},
  journal={Development},
  year={2011},
  volume={138 17},
  pages={3759-67}
}
Specification and determination (commitment) of positional identities precedes overt pattern formation during development. In the limb bud, it is clear that the anteroposterior axis is specified at a very early stage and is prepatterned by the mutually antagonistic interaction between Gli3 and Hand2. There is also evidence that the proximodistal axis is specified early and determined progressively. Little is known about upstream regulators of these processes or how epigenetic modifiers… CONTINUE READING

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