Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.

@article{Booth2018Ezh2AR,
  title={Ezh2 and Runx1 Mutations Collaborate to Initiate Lympho-Myeloid Leukemia in Early Thymic Progenitors.},
  author={Christopher A G Booth and Nikolaos Barkas and Wen Hao Neo and Hanane Boukarabila and Elizabeth J. Soilleux and George Giotopoulos and Noushin Farnoud and Alice Giustacchini and Neil Ashley and Joana Carrelha and Lauren Jamieson and Deborah Jane Atkinson and Tiphaine Bouriez-Jones and Rabinder K Prinjha and Thomas A Milne and David T Teachey and Elli Papaemmanuil and Brian J P Huntly and Sten Eirik W Jacobsen and Adam J Mead},
  journal={Cancer cell},
  year={2018},
  volume={33 2},
  pages={
          274-291.e8
        }
}
Lympho-myeloid restricted early thymic progenitors (ETPs) are postulated to be the cell of origin for ETP leukemias, a therapy-resistant leukemia associated with frequent co-occurrence of EZH2 and RUNX1 inactivating mutations, and constitutively activating signaling pathway mutations. In a mouse model, we demonstrate that Ezh2 and Runx1 inactivation targeted to early lymphoid progenitors causes a marked expansion of pre-leukemic ETPs, showing transcriptional signatures characteristic of ETP… CONTINUE READING
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