Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory

  title={Ezh2 Regulates Adult Hippocampal Neurogenesis and Memory},
  author={J. Zhang and F. Ji and Y. Liu and Xuepei Lei and Hong Li and G. Ji and Z. Yuan and Jianwei Jiao},
  journal={The Journal of Neuroscience},
  pages={5184 - 5199}
  • J. Zhang, F. Ji, +5 authors Jianwei Jiao
  • Published 2014
  • Biology, Medicine
  • The Journal of Neuroscience
  • Adult neurogenesis is thought to be crucial for preserving cognitive functions, which is tightly controlled by various epigenetic regulators. As the methyltransferase of histone H3K27, the role of Ezh2 in neurogenesis of adult mice and its mechanism of action are largely unknown. Here, we show that Ezh2 is expressed in actively dividing neural stem cells (NSCs)/progenitor cells as well as mature neurons, but not in quiescent NSCs in the subgranular zone. The deletion of Ezh2 in NSCs/progenitor… CONTINUE READING
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