Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.

@article{Pereira2010Ezh2TH,
  title={Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.},
  author={Joao Carlos Das Neves Pereira and Stephen N. Sansom and James Smith and Marc-Werner Dobenecker and Alexander Tarakhovsky and Frederick J. Livesey},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 36},
  pages={15957-62}
}
Multipotent progenitor cells of the cerebral cortex balance self-renewal and differentiation to produce complex neural lineages in a fixed temporal order in a cell-autonomous manner. We studied the role of the polycomb epigenetic system, a chromatin-based repressive mechanism, in controlling cortical progenitor cell self-renewal and differentiation. We found that the histone methyltransferase of polycomb repressive complex 2 (PCR2), enhancer of Zeste homolog 2 (Ezh2), is essential for… CONTINUE READING
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