Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats.

@article{Heek2003EzetimibePI,
  title={Ezetimibe potently inhibits cholesterol absorption but does not affect acute hepatic or intestinal cholesterol synthesis in rats.},
  author={Margaret van Heek and Constance Farley and Douglas S. Compton and Lizbeth M. Hoos and April Smith-Torhan and H. Richard Davis},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 8},
  pages={
          1459-64
        }
}
1. Ezetimibe (1-(4-fluorophenyl)-(3R)-[3-(4-fluorophenyl)-(3S)-hydroxypropyl]-(4S)-(4-hydroxyphenyl)-2-azetidinone) and its analog SCH48461 are potent and selective cholesterol absorption inhibitors that inhibit the transport of cholesterol across the intestinal wall, thereby lowering plasma cholesterol. 2. After a dose response for ezetimibe in rats was established, experiments were conducted to determine whether acute administration could alter hepatic or intestinal cholesterol synthesis. To… CONTINUE READING
Highly Cited
This paper has 45 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

New Treatments for Hypercholesterolemia

2005
View 3 Excerpts
Highly Influenced