Eye irritation responses in rabbit and man after single applications of equal volumes of undiluted model liquid detergent products.

@article{Roggeband2000EyeIR,
  title={Eye irritation responses in rabbit and man after single applications of equal volumes of undiluted model liquid detergent products.},
  author={R Roggeband and M. B. New York and Marc Pericoi and W. Braun},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2000},
  volume={38 8},
  pages={727-34}
}
A criticism of the use of the rabbit low-volume eye test to determine eye irritation hazard for man is the lack of comparative data in man and rabbit with undiluted products. To address this, such a study has been performed in man and rabbit using undiluted model liquid detergents. The hypothesis tested was that if, under identical test conditions, the effects in the rabbit were the same or greater than the response in man, then it is valid to use the low-volume eye test to assess eye… CONTINUE READING

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