Eye anomalies induced by cyclophosphamide in rat fetuses.

Abstract

Different eye anomalies, e.g. open eye (lid-gap), exophthalmos, cataractous lens, anophthalmia, microphthalmia, corneal opacities and absent lens were induced in rat fetuses by maternal administration of cyclophosphamide on the 12-16th day of gestation. 63-90% of anomalies were found in groups treated between days 13 and 15 of gestation. The 14th day of… (More)

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