Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta.

@article{Sandell2008ExuberantEO,
  title={Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta.},
  author={Linda J. Sandell and Xiaoyun Xing and Carl Franz and Steve G. Davies and L-W Chang and Debabrata Patra},
  journal={Osteoarthritis and cartilage},
  year={2008},
  volume={16 12},
  pages={
          1560-71
        }
}
OBJECTIVE To provide a more complete picture of the effect of interleukin-1 beta (IL-1beta) on adult human articular chondrocyte gene expression, in contrast to the candidate gene approach. DESIGN Chondrocytes from human knee cartilage were cultured in medium containing IL-1beta. Changes in gene expression were analyzed by microarray and reverse transcriptase-polymerase chain reaction analysis. The ability of transforming growth factor beta-1 (TGF-beta1), fibroblast growth factor (FGF)-18… CONTINUE READING
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