Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery.

Abstract

The aim of this study was to investigate extrusion-spheronization pelletization for preparing pH-sensitive matrix pellets for colon-specific drug delivery. The effects of three independent variables (amounts of Eudragit S, citric acid and spheronizing time) on pellet size, shape (roundness and aspect ratio), and drug release were studied with central… (More)

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Cite this paper

@article{Krogars2000ExtrusionspheronizationOP, title={Extrusion-spheronization of pH-sensitive polymeric matrix pellets for possible colonic drug delivery.}, author={Karin Krogars and Jyrki Hein{\"a}m{\"a}ki and J Vesalahti and Martti L. A. Marvola and Osmo Antikainen and Jouko K Yliruusi}, journal={International journal of pharmaceutics}, year={2000}, volume={199 2}, pages={187-94} }