Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats.

  title={Extrinsic surgical denervation ameliorates TNBS-induced colitis in rats.},
  author={Yoji Takami and Christopher R. Mantyh and Theodore N. Pappas and Toku Takahashi and Keiji Koda and Masaru Miyazaki},
  volume={56 91-92},
BACKGROUND/AIMS Neurogenic inflammation refers to an inflammatory reflex arc by sensory neurons which transmit nocious stimulus centrally and results in both pain perception and intense local inflammatory reaction. Specific neurons, receptors, and their respective neurotransmitters have been studied in numerous organ systems including the gastrointestinal tract. Neurogenic inflammation has been suggested to play a key role in the pathogenesis of inflammatory bowel disease. In this study, we… CONTINUE READING


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