Extrinsic pathway inhibitor--the key to feedback control of blood coagulation initiated by tissue thromboplastin.

@article{Sandset1991ExtrinsicPI,
  title={Extrinsic pathway inhibitor--the key to feedback control of blood coagulation initiated by tissue thromboplastin.},
  author={Per M Sandset and Ulrich Abildgaard},
  journal={Haemostasis},
  year={1991},
  volume={21 4},
  pages={219-39}
}
Extrinsic pathway inhibitor (EPI) is a Kunitz type serine protease inhibitor. EPI is a potent inhibitor of the factor VIIa/thromboplastin (TP) complex in the presence of factor Xa and is also a direct inhibitor of factor Xa. The inhibitory mechanism is complex and is currently thought to involve, in a first step, the formation of a EPI-factor Xa complex, and, in a second step, the formation a quaternary EPI-factor Xa-factor VIIa-TP complex. In the blood vessels, EPI is confined to three… CONTINUE READING

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