Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes.

@article{Tzellos2009ExtrinsicAI,
  title={Extrinsic ageing in the human skin is associated with alterations in the expression of hyaluronic acid and its metabolizing enzymes.},
  author={Thrasivoulos George Tzellos and Ioannis Klagas and Konstantinos Vahtsevanos and Stefanos K Triaridis and Athanasia Printza and Athanasios Kyrgidis and George Karakiulakis and C C Zouboulis and Eleni Papakonstantinou},
  journal={Experimental dermatology},
  year={2009},
  volume={18 12},
  pages={1028-35}
}
Extrinsic skin ageing or 'photoageing', as opposed to intrinsic skin ageing, is the result of exposure to external factors, mainly ultraviolet irradiation. Glycosaminoglycans (GAG) and particularly hyaluronic acid (HA) are major components of the cutaneous extracellular matrix involved in tissue repair. However, their involvement in extrinsic skin ageing remains elusive. In this study, we investigated the expression of HA and its metabolizing enzymes in photoexposed and photoprotected human… CONTINUE READING
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