Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.

@article{Cedzyski2007ExtremesOL,
  title={Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene.},
  author={Maciej Cedzyński and Lieve Nuytinck and Anne P M Atkinson and Anna St. Swierzko and Krzysztof Zeman and Janusz Szemraj and Agnieszka Szala and Marc L. Turner and David Chalmers Kilpatrick},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={150 1},
  pages={99-104}
}
L-ficolin (also called ficolin-2, P35 or hucolin) is a soluble pattern recognition molecule of suspected importance in anti-microbial immunity. It activates the lectin pathway of complement and acts as an opsonin. l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc. We report here data concerning four single nucleotide polymorphisms (SNPs) of the FCN2 gene and their relationship to l-ficolin serum concentrations. There are two… CONTINUE READING

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