Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans.

  title={Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans.},
  author={Maartje J. Luteijn and Petra van Bergeijk and Lucas J. T. Kaaij and Miguel Vasconcelos Almeida and Elke F. Roovers and Eugene Berezikov and Ren{\'e} F Ketting},
  journal={The EMBO journal},
  volume={31 16},
In recent years, the Piwi pathway has been shown to regulate the silencing of mobile genetic elements. However, we know little about how Piwi pathways impose silencing and even less about trans-generational stability of Piwi-induced silencing. We demonstrate that the Caenorhabditis elegans Piwi protein PRG-1 can initiate an extremely stable form of gene silencing on a transgenic, single-copy target. This type of silencing is faithfully maintained over tens of generations in the absence of a… CONTINUE READING
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