Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome.

@article{Warashina1999ExtremelyHA,
  title={Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome.},
  author={Masaki Warashina and Tomohiko Kuwabara and Yuka Nakamatsu and Kazunari Taira},
  journal={Chemistry & biology},
  year={1999},
  volume={6 4},
  pages={237-50}
}
BACKGROUND Chronic myelogenous leukemia (CML) results from chromosome 22 translocations (the Philadelphia chromosome) that creates BCR-ABL fusion genes, which encode two abnormal mRNAs (b3a2 and b2a2). Various attempts to design antisense oligonucleotides that specifically cleave abnormal L6 BCR-ABL fusion mRNA have not been successful. Because b2a2 mRNA cannot be effectively cleaved by hammerhead ribozymes near the BCR-ABL junction, it has proved very difficult to engineer specific cleavage of… CONTINUE READING
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