Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast

@article{Kayne1988ExtremelyCH,
  title={Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast},
  author={P. Kayne and Ung-Jin Kim and M. Han and J. Mullen and M. Grunstein},
  journal={Cell},
  year={1988},
  volume={55},
  pages={27-39}
}
  • P. Kayne, Ung-Jin Kim, +2 authors M. Grunstein
  • Published 1988
  • Biology, Medicine
  • Cell
  • Yeast histone H4 function was probed in vivo by deleting segments of this extremely conserved 102 amino acid protein. Deletions in the hydrophobic core of H4 are lethal and block chromosomal segregation. In contrast, deletions at the hydrophilic N terminus (residues 4-28) and C terminus (residues 100-102) are viable. However, N-terminal deletion alters normal chromatin structure and lengthens the cell cycle, especially G2. Surprisingly, removal of the H4 N terminus also derepresses the silent… CONTINUE READING
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